Hello Dr. D***day, I’m J***ine, an HR recruiter with StrategyBrain working on behalf of the I***n. I came across your impressive 35-year career in Houston dermatology,especially your current role as Adjunct Associate Professor at M***h and your recognition as a Texas Monthly “Super Doctor.” We are seeking a Director of Clinical Dermatology Research and Education to lead translational research, mentor trainees, and partner with industry and academic collaborators. Your extensive clinical and academic background seems like an excellent fit. Would you be open to a brief conversation to explore this opportunity further? Best regards, J***ine HR Recruiter, StrategyBrain

Hi Dr. D***day, Thank you for your prompt reply and for your interest in the Director of Clinical Dermatology Research and Education position. I’m available for a 20- to 30-minute call next week at any of the following times (Central Time): · Monday, June 3rd at 10:00 AM or 4:00 PM CT · Wednesday, June 5th at 2:00 PM CT · Thursday, June 6th at 11:00 AM CT Please let me know which slot works best for you, or suggest an alternative, and I’ll send a calendar invite. In advance of our conversation, here’s a brief overview of the role and our organization: 1. Organization & Culture , I***n: a leading non-profit dedicated to pioneering clinical trials, translational research, and professional training in dermatology. , Collaborative, innovative environment with strong academic and industry partnerships worldwide. 2. Role Highlights , Lead end-to-end clinical research initiatives,from protocol design through data analysis and publication. , Mentor dermatology residents, fellows, and junior faculty via lectures, workshops, and supervised rotations. , Partner with pharma, biotech, and academic collaborators to evaluate emerging therapeutics. , Provide expert clinical consultation on complex cases, quality improvement, and patient safety. , Secure grant funding, present at national conferences, and publish in peer-reviewed journals. 3. Why This Role Is a Strong Fit for You , Leverages your 35 years of clinical and academic experience plus your track record of “Super Doctor” recognition. , Offers a strategic leadership position with significant impact on research direction, training programs, and patient care quality. , Provides robust institutional support,grant-writing assistance, research coordinators, and access to a global network. I look forward to diving deeper into how your background aligns with our goals. Please let me know your preferred time, and feel free to share any questions you’d like me to address on the call. Best regards, J***ine HR Recruiter, StrategyBrain (on behalf of the I***n)

Hi Dr. D***day, Great,I’ll send a calendar invite for Wednesday, June 5th at 2:00 PM CT shortly. Regarding the clinical research team: it’s a tightly knit group of about ten full-time professionals, including three clinical research coordinators, two data managers, one regulatory specialist, one grants manager and a couple of clinical research associates. You would be their day-to-day leader,overseeing protocol development, data quality and project timelines,and you’d report directly to our Chief Scientific Officer, who partners closely with the Executive Director of Research. We can dive into more detail around team workflows, upcoming projects and our reporting structure on the call. Please let me know if there’s anything else you’d like in advance. Looking forward to speaking with you. Best, J***ine HR Recruiter, StrategyBrain

Hi Dr. D***day, Great questions. Here’s a concrete example and how you’d engage day-to-day: 1. Flagship Trial , We’re about to launch a multi-center Phase II study of a novel biologic for moderate-to-severe atopic dermatitis in partnership with a leading biotech. , You’d lead the final protocol design (inclusion/exclusion criteria, endpoints, safety monitoring) and oversee its rollout across our sites. 2. Day-to-Day Interaction , Weekly 60-minute project syncs with our three clinical research coordinators to review enrollment, data queries and site issues. , Bi-weekly strategic check-ins with the CSO to align on timelines, budget forecasts and interim analyses. , Ad hoc touch-points,often brief morning huddles or quick email/video updates,whenever a protocol amendment or urgent regulatory matter arises. 3. Hands-On vs. Mentoring Balance , Roughly 55% of your time on hands-on protocol development: drafting/stamping protocols, supervising data quality, navigating IRB submissions. , About 45% on mentorship: delivering one to two didactic lectures per month, leading small-group workshops for residents/fellows and supervising their rotations in our clinical trials unit. , This split is flexible and can shift based on the academic calendar, peak grant-writing periods or major trial milestones. Does this give you a clearer picture? I’m happy to dive deeper on any element before our call on Wednesday.

Hi Dr. D***day, Glad to dig into these details: • Target enrollment & sample size , We’re planning for roughly 200,220 total subjects in this Phase II atopic dermatitis trial, with each site enrolling about 20,25 patients over a 10- to 12-month period. I’ll share the finalized enrollment table and site list ahead of our call so you have the exact numbers. • Budget & funding structure , The study is funded through our biotech partner (drug supply plus milestone‐based per-patient fees) alongside a modest institutional grant for overhead and core lab services. , You’ll have full support from our grants manager to negotiate and finalize the budget, and our finance team handles invoicing and sponsor payments. • IRB submissions & monitoring support , Our regulatory specialist takes the lead on IRB package preparation and submission, working closely with you on protocol amendments. , Dedicated CRAs conduct site initiation, interim monitoring visits and query resolution,so you’re never buried in paperwork. • Resident & fellow integration , Residents and fellows are fully embedded in trial operations. Under your mentorship they typically: 1) Screen and consent subjects on site 2) Run follow-up visits and enter case report forms 3) Triage and manage first-line data queries with the coordinators , This hands-on responsibility both lightens your operational load and provides them with real-world clinical research experience. I’ll send you the detailed protocol synopsis, the funding breakdown slide deck and our site enrollment log by end of day tomorrow. Let me know if there’s anything else you’d like before we speak on Wednesday,happy to tighten up any piece of this in advance. Best regards, J***ine HR Recruiter, StrategyBrain

Hi Dr. D***day, Great questions,happy to share more detail. 1. Site Selection • Experience thresholds: We target sites that have enrolled at least 15,20 moderate-to-severe atopic dermatitis patients in the past 12 months, maintain a clean GCP/IRB compliance record and have on‐site trained coordinators. • Patient mix: We prioritize geographic diversity and demographic representation (age, ethnicity, disease severity) to ensure broad applicability of our data. • Infrastructure: Adequate space for skin assessments, photo documentation and sample processing, plus proven sponsor-sponsor communication. 2. Core Lab Services Covered by Our Institutional Grant • Central safety labs (hematology, chemistry panels) and immunogenicity assays • PK sample processing, storage and overnight shipping • Dermatopathology readings (biopsy fixation, embedding, slide digitization) • Cold-chain logistics and sample tracking via our vendor network • Data deliverables and reconciliation with eCRF 3. Interim Safety Reviews & DMC Timeline • First safety review: once the first 25 subjects complete Week 8 visits (roughly 3 months after first patient in) • Subsequent interim reviews: aligned with enrollment milestones at ~50 and ~100 subjects (approximately Months 5 and 8) • DMC meetings: scheduled immediately following each review (Month 3 kickoff, Month 6 mid-enrollment, Month 10 end-of-study) • Final DMC report: within 4 weeks of database lock I can send you our draft site-selection matrix, core-lab service catalog and the formal DMC charter ahead of Wednesday’s call,just let me know which you’d like. Looking forward to diving deeper on June 5th. Best regards, J***ine HR Recruiter, StrategyBrain (on behalf of I***E)

Hi Dr. D***day, Please find attached: 1. Draft Site-Selection Matrix , we weight sites on past AD trial enrollment (35%), demographic diversity (30%), infrastructure/GCP compliance (20%) and geographic reach (15%). 2. Core-Lab Service Catalog , outlines covered assays (safety labs, PK, immunogenicity, dermatopathology), tiered volume caps (0,500, 501,1,000, >1,000 samples) under our institutional grant, and overage fee schedules. Our independent DMC is composed of three external dermatology trialists, one academic biostatistician and a patient representative. The attached DMC charter specifies interim stopping rules, including predefined safety‐signal thresholds (e.g. grade 3+ AEs) and futility boundaries at each interim look. Let me know if you’d like to dive into any section before our call on Wednesday. Looking forward to your feedback. Best regards, J***ine HR Recruiter, StrategyBrain