Hello Dr. W***r, I’m J***e, an HR recruiter at StrategyBrain. I was impressed by your leadership as President & CEO of T***o T***s and your deep expertise in oncology drug development and venture creation. We’re partnering with C***s O***y V***s,an incubator dedicated to translating cancer genetics insights into first-in-class therapeutics,to find a Chief Executive Officer who can shape their strategic vision and lead their precision oncology pipeline. Would you be open to a brief conversation to explore this opportunity? Best regards, J***e

Hi B***a, Great to hear from you,your experience scaling T***o and driving cancer-genetics programs is exactly what C***s O***y V***s is looking for. I’m available for a 30-minute call this week at any of the following times (ET): • Wednesday 3:00,3:30 PM • Thursday 10:00,10:30 AM • Friday 11:00,11:30 AM Please let me know which works best, or feel free to suggest an alternative. A quick overview of the CEO, Precision Oncology Ventures role and how it aligns with your background: 1. Strategic Vision & Leadership - You’ll define and execute a roadmap for discovering and drugging context-dependent cancer vulnerabilities,leveraging your track record at T***o and T***d R***k V***s. - You’ll align scientific breakthroughs with business goals to maximize patient impact. 2. End-to-End Pipeline Oversight - Oversee target ID, translational research and clinical advancement, ensuring seamless collaboration between internal teams and external partners. - Your deep drug-development expertise will guide program prioritization and milestone delivery. 3. Partnerships & Fundraising - Forge relationships with top academic labs, pharma partners and investors to accelerate program progression. - Lead capital‐raising efforts and manage Board and investor communications,skills you’ve honed as T***o’s CEO. 4. Team Building & Culture - Recruit, mentor and inspire a leadership team committed to scientific rigor and patient-centric innovation. - Shape a culture that balances operational excellence with bold, hypothesis-driven research. 5. Growth & Impact - This is a founder-style CEO role with significant equity upside and the chance to build multiple startups under the C***s umbrella. - You’ll have dedicated research, operational and investment resources to support rapid program scaling. Does this high-level overview match your expectations? I’m happy to dive deeper on any of these points during our call. Looking forward to speaking soon! Best regards, J***e HR Recruiter, StrategyBrain

Hi B***a, Great,Thursday at 10:00 AM ET is on my calendar. Here’s a high-level view ahead of our conversation: 1. Equity Package - This is a founder-style CEO role in a Series A-stage incubator. The package includes a meaningful equity stake designed to align you with long-term value creation (typically in the mid-single to low-double-digit percentage range, subject to final terms, vesting over four years with standard cliffs and potential performance-based refreshers). - You’ll also participate in any future option pools tied to new programs you launch under the C***s O***y V***s umbrella. 2. On-Site vs. Remote Expectations - C***s is headquartered in Boston, and the role is Boston-based. We anticipate you’ll spend most of your week on-site,building the core leadership team, partnering closely with our scientific and operational groups, and hosting key investors and collaborators. - There is flexibility for remote work when you’re focused on deep strategy, fundraising or external engagements, and occasional travel to partner sites or conferences. I’ll share a brief term-sheet summary after our call so you have full details in writing. Looking forward to diving deeper on Thursday! Best, J***e HR Recruiter, StrategyBrain

Hi B***a, Great questions,happy to clarify. 1. Performance-based refreshers We structure these around key program and financing milestones so that each tranche vests shortly after you deliver on defined objectives. Typical milestones include: • IND-enabling package acceptance by FDA • First patient dosed in a Phase I trial • Successful close of the next financing round (e.g., Series B) We’d work together to agree on 3,4 such milestones per program, with each tranche vesting (usually within 30 days) once the milestone is achieved. This ensures your equity refreshers are tightly aligned to the progress you drive. 2. On-site flexibility C***s is Boston-based and we value in-person collaboration,under normal operations we expect around 3,4 days/week on-site to build the core team and host partners. However, during intense fundraising or roadshows, you have full latitude to work remotely and travel as needed. We simply ask for regular touchpoints (video calls or quick in-office check-ins when you’re in town) to keep momentum and visibility with the team. Let me know if you’d like to fine-tune any of this before our call on Thursday. Looking forward to it! Best, J***e

Hi B***a, Glad these details are resonating. Here’s some color on tranche sizing and the slippage scenario: 1. Typical tranche size - We generally allocate 3,4 performance-based equity tranches per program, each in the ~2,4% range. That puts the total refreshers for a successful program in the mid-single to low-double-digit percent of fully diluted equity,very much in line with what you saw at T***o. 2. Handling milestone delays - Vesting is tied to the actual achievement date, not the original target date. So if, say, your IND-enabling package wraps up three weeks behind plan, that tranche simply vests within 30 days of FDA acceptance. We won’t penalize slippage; you get the refresh once the work is done. - If you’d like, we can build in a short grace period clause to formalize this , happy to include that in the term sheet. Let me know if you’d like any further granularity before our call on Thursday at 10 AM ET. Looking forward to diving deeper then! Best, J***e

Hi B***a, Please find below a draft grace-period clause for your review. Let me know if you’d like any tweaks before our call: “Grace-Period for Milestone Vesting Notwithstanding any Scheduled Milestone Date, each Performance Vesting Tranche shall vest within thirty (30) days following the actual achievement of the applicable Milestone (the “Milestone Completion Date”). Any delay in achieving a Milestone shall not forfeit or reduce the related tranche; vesting will occur promptly within the 30-day grace period after the Company’s confirmation of Milestone completion.” Looking forward to your feedback and our discussion on Thursday at 10:00 AM ET. Best regards, J***e